I think fishing is always pretty good at Pickwick. I've been gong there since the mid-ninties and always catch fish. Of course, some years are better than others. Its an 7 hour run for me from NoKy but I keep going back, since its my best opportunity to catch fish consistently outside of Canada. Largemouth, smallmouth, drum, catfish - you never know what you will catch. 6lb2oz (2) Lgmouth are my tops, and a 23 inch smallie is my LTB down there. Of course they grown much larger. I tend to fish for quantity over quality and take what I get.
Spring is fun because everything is in play. While not necessarily a finesse guy, I do enjoy throwing plastics - lizards, bush hogs, grubs, etc.. Fall can get dicey because milfoil grows out about 20 feet from shore (pictured) in many of the places that you fish in the spring. I do well on the shelves/cliffs in the fall, and some Carolina rigging. It can get hot down there so I would suggest late September rather than early would be best. Lots of pleasure boaters and water lice.
I was down there for nine days this spring and did OK - not great. Water was up and murky with lots of wind. I am heading back down June 7-14th. There is a thread on here from my spring trip. We have been fishing spring on the North Channel of Lake Huron our of the Spanish River in Canda since 1991, but had that blown away this spring, ergo the second Pickwick trip.
Pictured below is the "milfoil" of which I speak, and a typical shale "cliff"/point that I do well on in the fall.