All the way...we did it from the dokis Indian reserve
BY BOAT with a motor? Holly crap - if so - that IS impressive (this is me bowing). That's like a zillion beer trip (everything on the river is measured in how many beers to get there and back)... Assume it was canoe (one way) which is still impressive...
LOVE THIS RIVER SYSTEM - you have been warned... Is the fishing as good as it was in the 70's when I was a kid - nope - then again - aside from Erie - where is?
Spent much of my youth on the system between Nipissing and Georgian bay... French, Pickerel, Wanapitei, Magnetawan, and the Key.... All similar (like flowing shield lakes) - white birch, white pine, rock, some spruce, and water - OH and BRONZEBACKS (that's a musky over 15kg in canuck terms - as their backs will turn bronze and they are KNOWN to wallow very shallow to sun themselves and infuriate anglers)...
Majority of my time was on Pickerel and Lower French - The more secluded the spot - the larger the musky, but the whole darn thing (from nip to GB) is much the same.
For musky - no secret - they love it LIVE - but anything that pisses them off will do. A majority of your strikes up there seem to be based on irritation of the fish - not seducing of the fish. Anyways - back troll the weed lines and points (usual spots). Best place on the river system for them - place called squal lake - but would take you forever to get there - and we reserved it for rainy days after July 4th. If you are musky fishing - remember - the one HUGE one you darn near ran over and are now throwing everything you got at it - is laughing at you. Chasing them rarely works - do your thing - if they choose you - then its on.
PIKE - different story... Need one lure (perhaps multiple copies would be a good backup) - 1oz - standard red stripe or black stripe Daredevil. Pick your spot like you would be trolling a harness for walleye then just troll or cast that spoon. Do not get discouraged by the hammer handles (the shear quantity) - the bigger ones are there - just keep throwing (and taking the croakers off)...
NOW if you venture all the way to Georgian Bay (GB) - the islands (some above water, most below) are heaven for the smaller pike (3-8lb class) - and you can catch them non-stop. Taking a boat with motor all the way down there can be tricky depending on water level and if you know where you are going...
Last note - At dusk - 18cm original GOLD rapala. Jerk through the water - erratic - IN running water - against the current - prefer more than a confluence - needs to be flowing water... Walleye - Pike - and Musky on this one - and its a sure thing if you find flow.